Rejuvenated hopes for an anti-aging pill

Written by: Captain Skellett // July 9th, 2009 // Recent Research

Meet rapamycin, our latest hope for the fountain of youth.

Rapamycin

Check out all those chiral centers, it’s freaking cyclical and everything!!! Can you BELIEVE it???

As published in Nature, the experiment went thusly: Researchers fed rapamycin to 20 month old mice (they were going to start earlier, but had apparently had some issues) and found that they lived much longer than the controls – 14% longer for females and 9% for males. This probably means Jack to you, so let me put it in human terms.

The treatment started when the mice were the equivalent of 60 years old, and it added an average of 13 years to their life. In the words of yon media release “this would be greater than the predicted increase in extra years of life if cancer and heart disease were both cured and prevented.” Wowzers. You couldn’t make that sound more dramatic if you TRIED!!!

As you would expect for something that looks so intricate, it’s made by a microbe. In this case, by a soil-dwelling bacteria called Streptomyces hygroscopicus. It is also known as sirolimus, and was first discovered on Easter Island in stunning want-to-go-there Polynesia.

Yeah, I think I'll do my research here...

The study of aging is called gerontology, and I was interested to read that one method to slow down the aging process is caloric restriction. Eat less, live longer. Now I feel bad about the giant bowl of pasta I had for dinner. Delicious though it may have been, was it really worth a week of my life?

Rapamycin inhibits cell division and the functionality of certain T-cells, and as such is used as an immunosuppressant to prevent post-transplant organ rejection, and is considered a potential chemotherapy agent. It’s also an antifungal. Interested in chemical synthesis? Who isn’t! Check it out here, yet another shameless Wikipedia plug brought to you by Captain Skellett 🙂

Now before we all get overexcited and start racing for old age, remember that mice are not little people! There are plenty of biological difference between people and mice, and the success of this trial does not mean that the road to a therapeutic will be easy. In fact, seeing as it’s currently being used as an immunosuppressant, it would actually be dangerous. That said, to quote Randy Strong, (love the name) Ph.D. “we believe this is the first convincing evidence that the aging process can be slowed and lifespan can be extended by a drug therapy starting at an advanced age,” and it represents a big-ass milestone on the road, rocky though it might be.

Captain Skellett

I be Captain Skellett. Me blog started in April 2009 when I was working full time and didn’t get a chance to talk science. Now I have changed jobs and talk science all the time, but that doesn’t stop me blogging. More About Captain Skellett   Google

   

2 Responses to “Rejuvenated hopes for an anti-aging pill”

  1. If this compound is safe, I do not mind volunteering for trial on myself. What clinical picture is usually followed pre- and post-adminstration of this pill?

    Kindly respond.

    Captain Skellett Reply:

    It’s surprising how many people have said this to me, even to the point of saying that they might just go to Easter Island and start eating dirt. THIS IS NOT A GOOD IDEA!!! First up, the rapamycin had to be packaged in a special capsule so that it was released in the intestines – so eating dirt would, at best, just give you dirty teeth (I’m pretty sure they were joking about eating dirt, but all the same…)

    I’m not sure how best to answer your question Prof. To be honest, Rapamycin as an anti-aging treatment is nowhere near entering human clinical trials, as far as I’m aware. Hell, it may not even get to that stage, I’m not even sure that they consider it a drug candidate. Plenty of things have one effect in mice and quite another in humans, and in humans Rapamycin is currently being used as an immunosuppressant, meaning that it weakens your immune system making you more susceptible to infections. I wouldn’t exactly call it safe, no drug is safe to mess around with.

    This research is exciting, but it is a LONG, LONG road to go from research to clinical trials, and another long road from clinical trials to the market.






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